Websense Security Labs' Predictions for 2010

  1. Web 2.0 attacks will increase in sophistication and prevalence 
  2. Botnet gangs will fight turf wars
  3. Email gains traction again as a top vector for malicious attacks
  4. Targeted attacks on Microsoft properties, including Windows 7 and Internet Explorer 8
  5. Don't Trust Your Search Results
  6. Smartphones are hackers' next playground
  7. Why corrupt a banner ad serve, when you can buy malvertising space?
  8. 2010 will prove once and for all that Macs are not immune to exploits

Source.